abstract：:Turmeric has been in use since ancient times as a condiment and due to its medicinal properties. Curcumin, the yellow colouring principle in turmeric, is polyphenolic and major active constituent. Besides anti-inflammatory, thrombolytic and anticarcinogenic activities, curcumin also possesses strong antioxidant proper...

journal_title：Neurochemical research

authors： Shukla PK,Khanna VK,Ali MM,Khan MY,Srimal RC

更新日期：2008-06-01 00:00:00

abstract：:Chronic administration to rats of mood-stabilizers that are effective against mania in bipolar disorder, is reported to downregulate markers of the brain arachidonic acid cascade. We hypothesized that chronic administration of lamotrigine, which is used to treat depression and rapid cycling in bipolar disorder, might ...

journal_title：Neurochemical research

authors： Lee HJ,Ertley RN,Rapoport SI,Bazinet RP,Rao JS

更新日期：2008-05-01 00:00:00

abstract：:During a variety of insults to the brain adenine nucleotides are released in large quantities from damaged cells, triggering multiple cellular responses to injury. Here, we evaluated changes in extracellular ATP, ADP and AMP hydrolysis at different times (0-24 hours) after unilateral cortical stab injury (CSI) in adul...

journal_title：Neurochemical research

authors： Nedeljkovic N,Bjelobaba I,Lavrnja I,Stojkov D,Pekovic S,Rakic L,Stojiljkovic M

更新日期：2008-05-01 00:00:00

abstract：:Since 1973, multiple effects of basic fibroblast growth factor have been described in a large number of cells. These effects include proliferation, survival and differentiation. The aim of this work was to study the intracellular pathways involved in the basic fibroblast growth factor (FGF2) effect on rat retinal cell...

journal_title：Neurochemical research

authors： Guilarducci-Ferraz CV,da Silva GM,Torres PM,Dos Santos AA,de Araújo EG

更新日期：2008-05-01 00:00:00

abstract：:During pregnancy, emergence of endogenous opioid inhibition of oxytocin neurons is revealed by increased oxytocin secretion after administration of the opioid receptor antagonist, naloxone. Here we show that prolonged estradiol-17beta and progesterone treatment (mimicking pregnancy levels) potentiates naloxone-induced...

journal_title：Neurochemical research

authors： Brown CH,Brunton PJ,Russell JA

更新日期：2008-04-01 00:00:00

abstract：:Increasing evidence indicates that adhesion molecules are critically involved in the regulation of mechanisms of synaptic plasticity including synapse formation, but also synaptic remodeling associated to changes in synaptic strength. Among these, the Neural Cell Adhesion Molecule (NCAM) and its polysialylated form PS...

journal_title：Neurochemical research

authors： Muller D,Mendez P,De Roo M,Klauser P,Steen S,Poglia L

更新日期：2008-03-20 00:00:00

abstract：:The release of the inhibitory neurotransmitter GABA is generally enhanced under potentially cell-damaging conditions. The properties and regulation of preloaded [3H]GABA release from mouse hippocampal slices were now studied in free radical-containing medium in a superfusion system. Free radical production was induced...

journal_title：Neurochemical research

authors： Saransaari P,Oja SS

更新日期：2008-03-01 00:00:00

abstract：:We have previously shown that angiotensin II (Ang II) stimulates astrocyte growth through activation of ERK1/2 mitogen activated protein (MAP) kinases. In the current study, we determined whether Ang II stimulates the expression of c-fos, c-jun and c-myc in brainstem astrocyte cultures. Reverse transcriptase-PCR analy...

journal_title：Neurochemical research

authors： Delaney J,Chiarello R,Villar D,Kandalam U,Castejon AM,Clark MA

更新日期：2008-03-01 00:00:00

abstract：:Brains of Alzheimer disease patients in early stages of dementia contain an increased 24(S)-hydroxycholesterol (cerebrosterol)/cholesterol ratio when compared to controls. In this study, effects of amyloid beta peptides and of racemic 24-hydroxycholesterol were evaluated in vitro on undepleted or cholesterol-depleted ...

journal_title：Neurochemical research

authors： Kristofiková Z,Kopecký V Jr,Hofbauerová K,Hovorková P,Rípová D

更新日期：2008-03-01 00:00:00

abstract：:Beta-amyloid (Abeta) peptides may cause malfunction and death of neurons in Alzheimer's disease. We investigated the effect of Abeta on key transporters of amino acid neurotransmission in cells cultured from rat cerebral cortex. The cultures were treated with Abeta(25-35) at 3 and 10 microM for 12 and 24 h followed by...

journal_title：Neurochemical research

authors： Buntup D,Skare O,Solbu TT,Chaudhry FA,Storm-Mathisen J,Thangnipon W

更新日期：2008-02-01 00:00:00

abstract：:The nerve agent VX has a variable and delayed absorption through the skin, which may have implications for treatment regimens. In the present study, central and peripheral effects of percutaneous VX intoxication were investigated in hairless guinea pigs. Although onset times of clinical signs varied considerably, the ...

journal_title：Neurochemical research

authors： Joosen MJ,van der Schans MJ,van Helden HP

更新日期：2008-02-01 00:00:00

abstract：:The human formyl peptide receptor like 1 (FPRL-1) is a variant of the Gi-coupled formyl-peptide receptor. Functional FPRL-1 is endogenously expressed in the U87 astrocytoma cell line and there is accumulating evidence to suggest that FPRL-1 may be involved in neuroinflammation associated with the pathogenesis of Alzhe...

journal_title：Neurochemical research

authors： Kwan DH,Kam AY,Wong YH

更新日期：2008-01-01 00:00:00

abstract：:Incubation of [3H]-tyrosine methionine5-enkephalin (MET) with human brain preparations (100,000g supernatant; sections of the limbic system, thalamus, basal ganglia, cerebellum, and cortex) results in its rapid and complete degradation; over 95% of the initial labeled tyrosine is recovered as the free aminoacid within...

journal_title：Neurochemical research

authors： Mosnaim AD,Nguyen TD,Tse R,Puente J,Couceyro P,Wolf ME

更新日期：2008-01-01 00:00:00

abstract：:Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we cha...

journal_title：Neurochemical research

authors： Jeon GS,Park SK,Park SW,Kim DW,Chung CK,Cho SS

更新日期：2008-01-01 00:00:00

abstract：:In the present work we investigated the in vitro effect of the branched-chain amino acids (BCAA) accumulating in maple syrup urine disease (MSUD) on some parameters of energy metabolism in cerebral cortex of rats. 14CO2 production from [1-14C]acetate, [1-5-14C]citrate and [U-14C]glucose, as well as glucose uptake by t...

journal_title：Neurochemical research

authors： Ribeiro CA,Sgaravatti AM,Rosa RB,Schuck PF,Grando V,Schmidt AL,Ferreira GC,Perry ML,Dutra-Filho CS,Wajner M

更新日期：2008-01-01 00:00:00

abstract：:The major breakthrough discovery of enkephalins as endogenous opiates led our attempts to determine their inactivation mechanisms. Because the NH2-terminal tyrosine is absolutely necessary for the neuropeptides to exert analgesic effects, and aminopeptidase activities are extraordinarily high in the brain, a specific ...

journal_title：Neurochemical research

authors： Hui KS

更新日期：2007-12-01 00:00:00

abstract：:The specific molecular events that underlie the age-related loss of cognitive function are poorly understood. Although not experimentally substantiated, age-dependent neuronal loss has long been considered central to age-related cognitive decline. More recently, age-related changes in brain white matter have taken pre...

journal_title：Neurochemical research

authors： Hinman JD,Abraham CR

更新日期：2007-12-01 00:00:00

abstract：:The amyloid peptide (Abeta) deposited in Alzheimer's disease (AD) is generated by beta- and gamma-secretase processing of a larger integral membrane protein precursor (APP). Intramembrane processing of APP by gamma-secretase also yields an intracellular fragment, CTFgamma (a.k.a. AICD), which is highly conserved and i...

journal_title：Neurochemical research

authors： Venugopal C,Pappolla MA,Sambamurti K

更新日期：2007-12-01 00:00:00

abstract：:It has been proposed that taurine may function as an oxidant in a dose-dependent manner in vivo and in vitro. The present study was carried out to investigate the relationship between taurine concentration and 3-nitrotyrosine level, a stable marker of peroxynitrite action, in hepatocytes of guinea pig in endotoxemia b...

journal_title：Neurochemical research

authors： Erdamar H,Türközkan N,Balabanli B,Ozan G,Bircan FS

更新日期：2007-11-01 00:00:00

abstract：:Cholinergic muscarinic receptors, when stimulated by arecoline, can activate cytosolic phospholipase A(2) (cPLA(2)) to release arachidonic acid (AA) from membrane phospholipid. This signal can be imaged in the brain in vivo using quantitative autoradiography following the intravenous injection of radiolabeled AA, as a...

journal_title：Neurochemical research

authors： Basselin M,Villacreses NE,Lee HJ,Bell JM,Rapoport SI

更新日期：2007-11-01 00:00:00

abstract：:Brief limb ischemia was reported to protect neurons against injury induced by subsequent cerebral ischemia-reperfusion, and this phenomenon is known as limb ischemic preconditioning (LIP). To explore the role of nitric oxide (NO) in neuroprotection of LIP in rats, we observed changes in the content of nitric oxide (NO...

journal_title：Neurochemical research

authors： Zhao HG,Sun XC,Xian XH,Li WB,Zhang M,Li QJ

更新日期：2007-11-01 00:00:00

abstract：:Recent evidence indicates that mechanisms involved in reward and mechanisms involved in learning interact, in that reward includes learning processes and learning includes reward processes. In spite of such interactions, reward and learning represent distinct functions. In the present study, as part of an examination ...

journal_title：Neurochemical research

authors： Fallon S,Shearman E,Sershen H,Lajtha A

更新日期：2007-10-01 00:00:00

abstract：:Alterations in lysosomal proteases have been implicated in many neurodegenerative diseases. The current study demonstrates a concentration-dependent decrease in PC12 cell viability and transient changes in cystatin C (CYSC), cathepsin B (CATB), cathepsin D (CATD) and caspase-3 following exposure to H2O2. Furthermore, ...

journal_title：Neurochemical research

authors： Lee DC,Mason CW,Goodman CB,Holder MS,Kirksey OW,Womble TA,Severs WB,Palm DE

更新日期：2007-09-01 00:00:00

abstract：:Tumor Necrosis Factor Receptor Super Family 6 gene (TNFRSF6), also known as FAS, encodes the Fas antigen, a cell surface receptor mediating cell apoptosis, situated on chromosome 10q located near the region of linkage to sporadic Alzheimer's disease (sAD). FAS levels have been reported elevated in the brain of AD pati...

journal_title：Neurochemical research

authors： Andreoli V,Nicoletti G,Romeo N,Condino F,La Russa A,Liguori M,Manna I,Spadafora P,Quattrone A,Cittadella R

更新日期：2007-09-01 00:00:00

abstract：UNLABELLED:Cirrhosis represents the terminal stage of a number of chronic liver diseases. Consequences include accumulation of toxic metabolic wastes, reduced synthesis of key proteins, increased portal venous pressure, and portosystemic shunting. We conducted a case-control study to assess the serum levels of S100B pr...

journal_title：Neurochemical research

authors： Ribeiro L,Andreazza AC,Salvador M,da Silveira TR,Vieira S,Nora DB,Bosa C,Di Napoli F,Schaf DV,Souza DO,Portela LV,Kapczinski F

更新日期：2007-09-01 00:00:00

abstract：:Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia in schizophrenic patients in a prolonged neuroleptic treatment course. Haloperidol (HAL) has been hypothesized to increase oxidative stress, while clozapine (CLO) would produce less oxidative damage. The objective was to determine ...

journal_title：Neurochemical research

authors： Agostinho FR,Jornada LK,Schröder N,Roesler R,Dal-Pizzol F,Quevedo J

更新日期：2007-08-01 00:00:00

abstract：:The potent parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is known to cause dopaminergic neurodegeneration in nigrostriatal system. In the present study we investigated the nuclear morphology of cells in the substantia nigra pars compacta (SNpc) region of rats following unilateral intra...

journal_title：Neurochemical research

authors： Banerjee R,Sreetama S,Saravanan KS,Dey SN,Mohanakumar KP

更新日期：2007-07-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluR) play a role in synaptic transmission, neuronal modulation and plasticity but their action in epileptic activity is still controversial. On the other hand adenosine acts as a neuromodulator with endogenous anticonvulsive properties. Since cerebellum from epileptic patients has s...

journal_title：Neurochemical research

authors： Girardi ES,Canitrot J,Antonelli M,González NN,Coirini H

更新日期：2007-07-01 00:00:00

abstract：:Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF), has been shown to attenuate the rotational behavior induced by D: -amphetamine and prevent the loss of dopaminergic neurons in the substantia nigra in rat models of Parkinson's disease. To examine if the neuroprotecti...

journal_title：Neurochemical research

authors： Xue B,Jiao J,Zhang L,Li KR,Gong YT,Xie JX,Wang XM

更新日期：2007-07-01 00:00:00

abstract：:One of the many pharmacological targets of ethanol is the GABA inhibitory system, and chronic ethanol (CE) is known to alter the polypeptide levels of the GABA(A )receptor subunits in rat brain regions. In the present study, we investigated the regulation of the tyrosine kinase phosphorylation of the GABA(A) receptor ...

journal_title：Neurochemical research

authors： Marutha Ravindran CR,Mehta AK,Ticku MK

更新日期：2007-07-01 00:00:00

abstract：:We investigated the effects of H(2)O(2)-induced oxidative stress on the delayed-rectifier current (IK(DR)), neuronal physiological and morphological properties. Measurements were obtained from hippocampal CA1 neurons in control solution and from the same neurons after exposure to oxidative stress (short- and long-term...

journal_title：Neurochemical research

authors： Hasan SM,Joe M,Alshuaib WB

更新日期：2007-07-01 00:00:00

abstract：:Pathophysiological concentrations of branched chain keto-acids (BCKAs), such as those that occur in maple syrup urine disease, inhibit oxygen consumption in liver homogenates and brain slices and the enzymatic activity of alpha-ketoglutarate- and pyruvate dehydrogenase complexes. Consistent with previous work, studies...

journal_title：Neurochemical research

authors： Shestopalov AI,Kristal BS

更新日期：2007-04-01 00:00:00

abstract：:Nitric oxide has been strongly implicated in the development of tissue infarction in response to focal cerebral ischemia. Nitric oxide and its derivatives can inhibit components of the electron transport chain, providing a likely target for these substances in ischemic and post-ischemic brain. Lactate content is incre...

journal_title：Neurochemical research

authors： Helps SC,Sims NR

更新日期：2007-04-01 00:00:00

abstract：:Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood...

journal_title：Neurochemical research

authors： Jope RS,Yuskaitis CJ,Beurel E

更新日期：2007-04-01 00:00:00

abstract：:A number of recent findings support the notion of mechanistic parallels between Alzheimer disease (AD) and oncogenic processes, specifically, that neurons in AD, like cancer cells, display aberrant mitotic cell cycle re-entry. However, the mechanism that drives postmitotic neurons to reenter cell cycle remains elusive...

journal_title：Neurochemical research

authors： Previll LA,Crosby ME,Castellani RJ,Bowser R,Perry G,Smith MA,Zhu X

更新日期：2007-04-01 00:00:00

abstract：:Salsolinol, an endogenous neurotoxin, is known to be involved in the pathogenesis of Parkinson's disease (PD). In the present study, we have investigated the effects of salsolinol on the activation of two different signaling pathways that involve c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB, (NF-kappaB) in...

journal_title：Neurochemical research

authors： Wanpen S,Kooncumchoo P,Shavali S,Govitrapong P,Ebadi M

更新日期：2007-03-01 00:00:00

abstract：:Diurnal changes in Chordc1 mRNA were recently described in mouse hypothalamus. This report shows that Chordc1 mRNA changes rhythmically throughout the entire adult brain with highest expression levels occurring around the dark-light transition. The rhythmic cycling pattern of Chordc1 was retained under various light-d...

journal_title：Neurochemical research

authors： Gerstner JR,Landry CF

更新日期：2007-02-01 00:00:00

abstract：:Glutamate and its receptors are expressed very early during development and may play important roles in neurogenesis, synapse formation and brain wiring. The levels of glutamate and activity of its receptors can be influenced by exogenous factors, leading to neurodevelopmental disorders. To investigate the role of NMD...

journal_title：Neurochemical research

authors： Ghiani CA,Beltran-Parrazal L,Sforza DM,Malvar JS,Seksenyan A,Cole R,Smith DJ,Charles A,Ferchmin PA,de Vellis J

更新日期：2007-02-01 00:00:00

abstract：:The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate. Caspase-independent death caused by high levels of NO is also partially prevented by 8-Br-cGMP. Inhibitors of protein kinase G (cGM...

journal_title：Neurochemical research

authors： Benjamins JA,Nedelkoska L

更新日期：2007-02-01 00:00:00

abstract：:CNTF (ciliary neurotrophic factor) has been suggested to be an important survival factor for oligodendrocytes; however, this effect is inconsistently obtained and myelination appears normal in CNTF null animals. On the other hand, CNTF stimulates astrocytes to produce growth and trophic factors. Therefore, we tested t...

journal_title：Neurochemical research

authors： Albrecht PJ,Enterline JC,Cromer J,Levison SW

更新日期：2007-02-01 00:00:00